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Homeobox protein goosecoid is a protein that in humans is encoded by the ''GSC'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=145258 )〕 This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.〔 Koller's sickle is the first to express the chick homeobox gene ''goosecoid'' (GSC). == Function == The GSC gene defines neural-crest cell-fate specification and contributes to dorsal - ventral patterning. Over activation in ''Xenopus'' promotes dorso-anterior migration and dorsalization of mesodermal tissue of the cells along with BMP-4. Conversely, loss-of-functions analysis indirectly prevented head formation in ''Xenopus'' and head defects in zebrafish. Although, knock-out studies in mice showed that the GSC gene is not required for gastrulation but there is still reduction of the base of the cranium. A mutation in the GSC gene in ''Drosophila'' is lethal. Gsc gene promotes the formation of Spemann’s Organizer. This organizer prevents BMP-4 from inducing the ectoderm in the future head region of the embryo to become epidermis; it instead allows the future head region to form neural folds, which will eventually turn into the brain and spinal cord. For normal anterior development to occur, Spemann’s organizer cannot express the Xwnt-8 or BMP-4 transcription factors. Gsc directly represses the expression of Xwnt-8 while indirectly repressing BMP-4. The inhibition of Xwnt-8 and BMP-4 ensures that normal anterior development, promoted by Spemann’s organizer, can occur. The expression of Gsc occurs twice in development, first during gastrulation and second during organogenesis. Gsc is found in high concentrations in the dorsal mesoderm and endoderm during gastrulation. The later expression of Gsc is confined to the head region. In the Xenopus, cells that express Gsc become the pharyngeal endoderm, the head mesoderm, and the notocord. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「GSC (gene)」の詳細全文を読む スポンサード リンク
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